Non-traditional risk factors for cardiovascular events: a clinical case of transient Brugada syndrome
https://doi.org/10.24884/1609-2201-2025-104-3-68-75
Abstract
Brugada syndrome is an inherited channelopathy characterized by specific electrocardiographic (ECG) abnormalities, an increased risk of life-threatening ventricular arrhythmias, and sudden cardiac death. Despite the classical presentation of a stable type 1 ECG pattern, it is known that some patients exhibit transient manifestations, which complicates diagnosis and treatment strategy selection. This article presents a clinical case of transient Brugada syndrome and discusses the diagnostic approach when this pathology is suspected. The study of this phenomenon is highly relevant, as the dynamic variability of ECG findings and the often-subtle clinical presentation hinder timely diagnosis, thereby increasing the risk of sudden, potentially fatal arrhythmias.
About the Authors
G. G. Bakulin
Saint Petersburg State University; Corporate Group
Russian Federation
Russian Federation
Gennady G. Bakulin, postgraduate student at the Department of Hospital Therapy, Faculty of Medicine
8a, 21st line of V. O., Saint Petersburg, 199106
N. G. Ostanina
Saint Petersburg State University; Alexandrovskaya Hospital
Russian Federation
Russian Federation
Nina G. Ostanina, Cand. of Sci. (Med.), Cardiologist
Saint Petersburg
A. G. Obrezan
Saint Petersburg State University; Corporate Group
Russian Federation
Russian Federation
Andrey G. Obrezan, Dr. of Sci. (Med.), Professor, Head of the Department of Hospital Therapy, Faculty of Medicine, Chief Physician
Saint Petersburg
References
1. Antzelevitch C., Patocskai B. Brugada syndrome: clinical, genetic, molecular, cellular, and ionic aspects. Curr Probl Cardiol. 2016;41:7–57. https://doi.org/10.1016/j.cpcardiol.2015.06.0022.
2. Brugada P., Brugada J. Right bundle branch block, persistent ST segment elevation, and sudden cardiac death: a distinct clinical and electrocardiographic syndrome: a multicenter report. J Am Coll Cardiol. 1992;20:1391–1396. https://doi.org/10.1016/0735-1097(92)90253-j.
3. Vutthikraivit W., Rattanawong P., Putthapiban P. et al. Worldwide prevalence of Brugada syndrome: a systematic review and meta-analysis. Acta Cardiol Sin. 2018;34:267–277. https://doi.org/10.6515/ACS.201805_34(3).20180302B.
4. Priori S. G., Blomström-Lundqvist C., Mazzanti A. et al. 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC). Europace. 2015;17:1601–1687. https://doi.org/10.1093/europace/euv319.
5. Cerrone M., Costa S., Delmar M. The genetics of Brugada syndrome. Annu Rev Genomics Hum Genet. 2022;23:255–274. https://doi.org/10.1146/annurev-genom-112921-011200.
6. Veerman C. C., Wilde A. A. M., Lodder E. M. The cardiac sodium channel gene SCN5A and its gene product NaV1.5: role in physiology and pathophysiology. Gene. 2015;573:177–187. https://doi.org/10.1016/j.gene.2015.07.062
7. Coppola G., Corrado E., Curnis A. et al. Update on Brugada syndrome 2019. Curr Probl Cardiol. 2019;44:100454. https://doi.org/10.1016/j.cpcardiol.2019.100454.
8. Antzelevitch C., Yan G. X., Ackerman M. J. et al. J-wave syndromes expert consensus conference report: emerging concepts and gaps in knowledge. Heart Rhythm. 2016;13(10):e295–324. https://doi.org/10.1016/j.hrthm.2016.05.014.
9. Papadakis M., Papatheodorou E., Mellor G. et al. The diagnostic yield of Brugada syndrome after sudden death with normal autopsy. J Am Coll Cardiol. 2018;71:1204–1214. https://doi.org/10.1016/j.jacc.2018.03.103.
10. Al-Khatib S. M., Stevenson W. G., Ackerman M. J. et al. 2017 AHA/ ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary. Heart Rhythm. 2018;15:e73–e189. https://doi.org/10.1016/j.hrthm.2017.10.035.
11. Bokeriya L. A., Serguladze S. Y., Pronicheva I. V. et al. Russian Society of Cardiovascular Surgeons. Brugada syndrome. Clinical recommendations. 2020. (In Russ.). URL: http://racvs.ru/clinic/files/2020/brugada. pdf (accessed: 10.10.25).
12. Priori S. G., Wilde A. A., Horie M. et al. HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Heart Rhythm. 2013;10(12):1932–1963. https://doi.org/10.1016/j.hrthm.2013.05.014.
13. Brugada J., Campuzano O., Arbelo E. et al. Present status of Brugada syndrome: JACC state-of-the-art review. J Am Coll Cardiol. 2018;72:1046–1059. https://doi.org/10.1016/j.jacc.2018.06.037.
Review
For citations:
Bakulin G.G., Ostanina N.G., Obrezan A.G. Non-traditional risk factors for cardiovascular events: a clinical case of transient Brugada syndrome. New St. Petersburg Medical Records. 2025;(3):68-75. (In Russ.) https://doi.org/10.24884/1609-2201-2025-104-3-68-75
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