spbmedicalrecordsНовые Санкт-Петербургские врачебные ведомостиNew St. Petersburg Medical Records1609-2201Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова10.24884/1609-2201-2025-104-2-82-84spbmedicalrecords-93Research ArticleТЕЗИСЫ КОНКУРСА МОЛОДЫХ УЧЕНЫХABSTRACTS OF THE COMPETITION FOR YOUNG SCIENTISTSTAS2R как компоненты патогенеза респираторных заболеванийTAS2R as components of the pathogenesis of respiratory diseaseshttps://orcid.org/0009-0004-2113-5200МуркинаР. Г.MurkinaR. G.

Муркина Рахиль Геннадьевна, ординатор 1 года по направлению «ревматология»

197022, Санкт-Петербург, ул. Льва Толстого, д. 6–8

Rakhil G. Murkina, 1st year Resident of the Direction of General Doctor (Rheumatology)

6–8, L’va Tolstogo str., Saint Petersburg, 197022

mrg1327x@inbox.ruhttps://orcid.org/0000-0002-1268-9795НёмаМ. А.NyomaM. A.

Нёма Михаил Александрович, кандидат медицинских наук, доцент кафедры госпитальной терапии с курсом аллергологии и иммунологии имени академика М. В. Черноруцкого с клиникой

Санкт-Петербург

 

Mikhail A. Nyoma, Cand. of Sci. (Med.), Associate Professor of the Department of Hospital Therapy with the Course of Allergology and Immunology named after Acad. M. V. Chernorutsky with Clinic

Saint Petersburg

nyoma1@yandex.ruhttps://orcid.org/0000-0003-0352-8137МинеевВ. Н.MineevV. N.

Минеев Валерий Николаевич, доктор медицинских наук, профессор кафедры госпитальной терапии с курсом аллергологии и иммунологии имени академика М. В. Черноруцкого с клиникой

Санкт-Петербург

 

Valery N. Mineev, Dr. of Sci. (Med.), Professor of the Department of Hospital Therapy with the Course of Allergology and Immunology named after Acad. M. V. Chernorutsky with Clinic

Saint Petersburg

vnmineev@mail.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И. П. ПавловаРоссияPavlov UniversityRussian Federation202506112025028284Copyright © Муркина Р.Г., Нёма М.А., Минеев В.Н., 20252025Муркина Р.Г., Нёма М.А., Минеев В.Н.Murkina R.G., Nyoma M.A., Mineev V.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.docved.ru/jour/article/view/93

Настоящая работа посвящена изучению роли эктопических рецепторов к горькому вкусу (TAS2R) в патогенезе заболеваний органов дыхания. Предоставляются данные о механизме трансдукции сигнала от вкусовых рецепторов, опосредованном G-белком. Приводятся сведения об участии TAS2R рецепторов в системе местной защиты в реснитчатом эпителии дыхательных путей, его активации молекулами системы «quorum sensing» и связи с компонентами мукоцилиарного клиренса. Кроме того, рецепторы TAS2R рассматриваются и как структуры, ассоциированные с аллергическими заболеваниями, в частности с бронхиальной астмой.

The present work investigates the role of ectopic bitter taste receptors (TAS2R) in the pathogenesis of respiratory diseases. Data are provided on the mechanism of G-protein-mediated signal transduction from taste receptors. Participation of TAS2R in the local protective mechanisms in a ciliated epithelium of the respiratory tract and its activation by «quorum sensing» system molecules and its connection with the components of mucociliary clearance are presented. In addition, TAS2R receptors are also considered to be associated with allergic diseases, in particular – with bronchial asthma.

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The authors declare that there are no conflicts of interest present.