spbmedicalrecordsНовые Санкт-Петербургские врачебные ведомостиNew St. Petersburg Medical Records1609-2201Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова10.24884/1609-2201-2024-103-4-26-30spbmedicalrecords-41Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSРоль рецепторов TAS2R и транскрипционного фактора SREBP-2 в патогенезе респираторных заболеванийRole of TAS2R and transcription factor SREBP-2 in pathogenesis of respiratory diseaseshttps://orcid.org/0000-0002-1268-9795НёмаМ. А.NyomaM. A.

Нёма Михаил Александрович - кандидат медицинских наук, доцент кафедры госпитальной терапии имени ак. М. В. Черноруцкого с клиникой.

197022, Санкт-Петербург, ул. Льва Толстого, д. 6‒8

Mikhail A. Nyoma - Cand. of Sci. (Med.), Associate Professor, M. Chernorutsky Hospital Therapy Department.

6‒8, L’va Tolstogo str., Saint Petersburg, 197022, +7-904-333-85-67

nyoma1@yandex.ruhttps://orcid.org/0009-0004-2113-5200МуркинаР. Г.MurkinaR. G.

Муркина Рахиль Геннадьевна - ординатор 1 года.

Санкт-Петербург

Rakhil G. Murkina - 1st year Resident.

Saint Petersburg

mrg1327x@inbox.ruhttps://orcid.org/0009-0008-8014-4608СадоваяВ. В.SadovayaV. V.

Садовая Виктория Валериевна - студентка 6 курса.

Санкт-Петербург

Victoria V. Sadovaya - 6th year student.

Saint Petersburg

viktorya@yandex.ruhttps://orcid.org/0000-0003-0352-8137МинеевВ. Н.MineevV. N.

Минеев Валерий Николаевич - доктор медицинских наук, профессор кафедры госпитальной терапии имени ак. М. В. Черноруцкого.

Санкт-Петербург

Valery N. Mineev - Dr. of Sci. (Med.), Professor, M. Chernorutsky Hospital Therapy Department.

Saint Petersburg

vnmineev@mail.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаРоссияPavlov UniversityRussian Federation202418032025042630Copyright © Нёма М.А., Муркина Р.Г., Садовая В.В., Минеев В.Н., 20252025Нёма М.А., Муркина Р.Г., Садовая В.В., Минеев В.Н.Nyoma M.A., Murkina R.G., Sadovaya V.V., Mineev V.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.docved.ru/jour/article/view/41

В настоящее время появляется все больше данных об экстраоральных рецепторах к горькому вкусу (TAS2R). В обзоре приводятся современные данные по транскрипционному фактору SREBP-2, его вкладе в обмен холестерина и об участии TAS2R в системе местной защиты в реснитчатом эпителии дыхательных путей и его активации молекулами системы «quorum sensing» и связи его с компонентами мукоцилиарного клиренса.

В отношении роли экстраоральных TAS2R и регуляции их экспрессии остается много неясного, что требует дальнейших исследований, в том числе в области респираторной патологии.

More and more new data, concerning extraoral bitter taste receptors (TAS2R), appear now. Current data on SREBP-2, its role in cholesterol synthesis, participation of TAS2R in the local protective mechanisms in a ciliated epithelium of the respiratory tract and its activation by “quorum sensing” system molecules and its connection with the components of mucociliary clearance are presented.

The role of extraoral TAS2Rs and mechanisms of its regulation remain uncertain, that requires further research, including the field of respiratory pathology.

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The authors declare that there are no conflicts of interest present.