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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">spbmedicalrecords</journal-id><journal-title-group><journal-title xml:lang="ru">Новые Санкт-Петербургские врачебные ведомости</journal-title><trans-title-group xml:lang="en"><trans-title>New St. Petersburg Medical Records</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-2201</issn><publisher><publisher-name>Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1609-2201-2024-103-2-57-60</article-id><article-id custom-type="elpub" pub-id-type="custom">spbmedicalrecords-21</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Фатальные поражения кишечника при коронавирусной инфекции</article-title><trans-title-group xml:lang="en"><trans-title>Fatal intestinal lesions in coronavirus infection</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9972-0304</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катюхин</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Katyukhin</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Катюхин Валерий Николаевич, доктор медицинских наук, профессор, заведующий кафедрой внутренних болезней</p><p>199098, Санкт-Петербург, ул. Калинина, д. 8, корпус 2, лит. А</p></bio><bio xml:lang="en"><p>Valery N. Katyukhin, Dr. of Sci. (Med.), Professor, Head of Department of Internal Medicine</p><p>8, Kalinina St., building 2, lit. A., Saint Petersburg, 199098</p></bio><email xlink:type="simple">kvnpni@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-6129-8060</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авакян</surname><given-names>К. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Avakyan</surname><given-names>K. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Авакян Карапет Леонович, заведующий патологоанатомическим отделением</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Karapet L. Avakyan, Head of Pathology Department</p><p>Saint Petersburg</p></bio><email xlink:type="simple">avagyan.k@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8339-0651</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хадикова</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Khadikova</surname><given-names>N. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хадикова Надежда Георгиевна, кандидат медицинских наук, доцент кафедры внутренних болезней, заместитель главного врача по терапии</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Nadezhda G. Khadikova, Cand. of Sci. (Med.), Associate Professor, Department of Internal Medicine, Deputy Chief Physician for Internal Medicine</p><p>Saint Petersburg</p></bio><email xlink:type="simple">khadikova@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Университет РЕАВИЗ<country>Россия</country></aff><aff xml:lang="en">Medical University «Reaviz»<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Николаевская больница<country>Россия</country></aff><aff xml:lang="en">Nikolaev Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Университет РЕАВИЗ ; Николаевская больница<country>Россия</country></aff><aff xml:lang="en">Medical University «Reaviz» ; Nikolaev Hospital<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>01</day><month>11</month><year>2024</year></pub-date><volume>0</volume><issue>2</issue><fpage>57</fpage><lpage>60</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Катюхин В.Н., Авакян К.Л., Хадикова Н.Г., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Катюхин В.Н., Авакян К.Л., Хадикова Н.Г.</copyright-holder><copyright-holder xml:lang="en">Katyukhin V.N., Avakyan K.L., Khadikova N.G.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.docved.ru/jour/article/view/21">https://www.docved.ru/jour/article/view/21</self-uri><abstract><p>В клинике коронавирусной инфекции (SARS-CoV-2) преобладают воспалительные симптомы верхних дыхательных путей и легочной паренхимы, а поражение кишечника и появление пищеварительных симптомов более характерны для длительно текущей патологии. Цель исследования – ретроспективно проанализировать летальные случаи поражений кишечника при новой инфекции COVID-19. Всего выявлено 9 больных со смертельными поражениями кишечника из общего количества 2781 летальных исходов за 3 года работы стационара «Николаевской больницы» Санкт-Петербурга, перепрофилированной для оказания медицинской помощи больным с новой коронавирусной инфекцией COVID-19 (SARS-CoV-2). Описанные патологоанатомические проявления в виде тромбозов мезентериальных сосудов и некроза стенки, соответствующие определению «фатальное поражение кишечника», признаны состояниями, несовместимыми с жизнью и непредотвратимыми на этапе квалифицированной и специализированной терапевтической помощи.</p></abstract><trans-abstract xml:lang="en"><p>In the clinic of coronavirus infection (SARS-CoV-2), inflammatory symptoms of the upper respiratory tract and pulmonary parenchyma prevail, and intestinal damage and the appearance of digestive symptoms are more characteristic of long-term pathology. The aim of the study was to retrospective analyze fatal cases of intestinal lesions in a new Covid-19 infection. In total, 9 patients with fatal intestinal lesions were identified out of a total of 2,781 deaths during the three years of operation of the Nikolaevskaya Hospital hospital in St. Petersburg, which was repurposed to provide medical care to patients with the new coronavirus infection Covid-19 (SARS-Cov-2). The described pathoanatomical manifestations in the form of mesenteric vascular thrombosis and wall necrosis, corresponding to the clinical definition of «fatal intestinal lesion», are recognized as conditions incompatible with life and unavoidable at the stage of qualified and specialized therapeutic care.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>коронавирусная инфекция (SARS-CoV-2)</kwd><kwd>фатальные поражения кишечника</kwd><kwd>непредотвратимые состояния</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronavirus infection (SARS-CoV-2)</kwd><kwd>fatal intestinal lesions</kwd><kwd>unavoidable conditions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Katyukhin V. N. Consequens of coronovirus infection: Clinical manifestations, diagnosis and treatment tactics // EC Clinical and Medical Case Reports. 2023. Vol. 6, no. 11. P. 01–05.</mixed-citation><mixed-citation xml:lang="en">Katyukhin V. N. Consequens of Coronovirus Infection: Clinical Manifestations, Diagnosis and Treatment Tactics. EC Clinical and Medical Case Reports. 2023;6(11):01–05.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Berenguera A., Jacques-Aviñó C., Medina-Perucha L., Puente D. Long term consequences of COVID-19 // Eur. J. Intern. Med. 2021. Vol. 9. P. 34–35. DOI: 10.1016/j.ejim.2021.08.022.</mixed-citation><mixed-citation xml:lang="en">Berenguera A., Jacques-Aviñó C., Medina-Perucha L., Puente D. Long term consequences of COVID-19. Eur. J. Intern. Med. 2021;9:34–35. DOI: 10.1016/j.ejim.2021.08.022.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Carfì A., Bernabei R., Landi F. Persistent symptoms in patients after acute COVID-19 // JAMA. 2020. Vol. 324, no. 6. P. 603–605. DOI: 10.1001/jama.2020.12603.</mixed-citation><mixed-citation xml:lang="en">Carfì A., Bernabei R., Landi F. Persistent symptoms in patients after acute COVID-19. JAMA. 2020;324(6):603–605. DOI: 10.1001/jama.2020.12603.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Arnold D. T., Hamilton F. W., Milne A. et al. Patient outcomes after hospitalization with COVID-19 and implications for follow-up: results from a prospective UK cohort // Thorax. 2021. Vol. 76, no. 4. P. 399–401. DOI: 10.1136/thoraxjnl-2020-216086.</mixed-citation><mixed-citation xml:lang="en">Arnold D. T., Hamilton F. W., Milne A. et al. Patient outcomes after hospitalization with COVID-19 and implications for follow-up: results from a prospective UK cohort. Thorax. 2021;76(4):399– 401. DOI: 10.1136/thoraxjnl-2020-216086.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Сарсенбаева А. С., Лазебник Л. Б. Особенности поражения кишечника при COVID-19 // Экспериментальная и клиническая гастроэнтерология. 2020. № 12. С. 16–22. DOI: 10.31146/1682-8658-ecg-184-12-16-22.</mixed-citation><mixed-citation xml:lang="en">Sarsenbaeva A. S., Lazebnik L. B. Features of intestinal lesions in COVID-19. Experimental and Clinical Gastroenterology. 2020;(12):16–22. (In Russ). DOI: 10.31146/1682-8658-ecg-184-12-16-22.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Uhlenhopp D. J., Ramachandran R., Then E. at al. COVID-19-associated ischemic colitis: A rare manifestation of COVID-19 infection-case report and review // J. Investig. Med. High Impact Case Rep. 2022. Vol. 10. P. 23247096211065625. DOI: 10.1177/23247096211065625. PMID: 35343847; PMCID: PMC8966066.</mixed-citation><mixed-citation xml:lang="en">Uhlenhopp D. J., Ramachandran R., Then E. at al. COVID-19-Associated Ischemic Colitis: A Rare Manifestation of COVID-19 Infection-Case Report and Review. J. Investig. Med. High Impact Case Rep. 2022;10:23247096211065625. DOI: 10.1177/23247096211065625. PMID: 35343847; PMCID: PMC8966066.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Профилактика, диагностика и лечение новой коронавирусной инфекции (covid-19) : Временные методические рекомендации. Версия 18 (26.10.2023). МЗ РФ. URL: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/064/610/original/%D0%92%D0%9C%D0%A0_COVID-19_V18.pdf (дата обращения: 20.08.24).</mixed-citation><mixed-citation xml:lang="en">Prevention, diagnosis and treatment of novel coronavirus infection (covid-19) : Interim methodological recommendations. Version 18 (26.10.2023). Ministry Of Health Of The Russian Federation. URL: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/064/610/original/%D0%92%D0%9C%D0%A0_COVID-19_V18.pdf (accessed: 20.08.24). (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьева Н. А., Воробьева А. И., Воронцова А. С. Прогнозирование риска развития протромбогенной готовности при инфекции Covid-19 с использованием генетического тестирования // Анализ риска здоровью. 2023. Т. 2. С. 130–139. DOI: 10.21668/health.risk/2023.2.12.</mixed-citation><mixed-citation xml:lang="en">Vorobyeva N. A., Vorobyeva A. I., Vorontsova A. S. Predicting the risk of prothrombogenic readiness in Covid-19 infection using genetic testing. Health Risk Analysis. 2023;2:130–139. (In Russ). DOI: 10.21668/health.risk/2023.2.12.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
