spbmedicalrecordsНовые Санкт-Петербургские врачебные ведомостиNew St. Petersburg Medical Records1609-2201Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова10.24884/1609-2201-2024-103-2-25-33spbmedicalrecords-17Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSВлияние мелатонина на развитие ожиренияInfluence of melatonin on the development of obesityhttps://orcid.org/0009-0006-0764-8725ЮсуповА. В.YusupovA. V.

Юсупов Алексей Владиславович, курсант

Санкт-Петербург

Alexey Yusupov V., cadet

St. Petersburg

alexeyiusupov@mail.ruЛиходкинВ. А.LikhodkinV. A.

Лиходкин Вадим Александрович, клинический ординатор по специальности «Терапия»

194044, Санкт-Петербург, ул. Академика Лебедева, 6

Vadim Likhodkin A., clinical resident in the specialty “Therapy”

6, Academician Lebedev Street, Saint Petersburg, 194044

likhodkin.vadim@yandex.ruВоенно-медицинская академия имени С. М. КироваРоссияS. M. Kirov Military Medical AcademyRussian FederationВоенно-медицинская академия имени С. М. КироваРоссияS. M. Kirov Military medical academyRussian Federation202401112024022533Copyright © Юсупов А.В., Лиходкин В.А., 20242024Юсупов А.В., Лиходкин В.А.Yusupov A.V., Likhodkin V.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.docved.ru/jour/article/view/17

В последние годы все большее внимание исследователей уделяется роли мелатонина в регуляции массы тела. При анализе данных литературы рассматривается проблема механизма действия мелатонина на организм и его применения в коррекции метаболических нарушений. Расстройство циркадных ритмов, вызванное использованием искусственного освещения в ночное время, приводит к снижению секреции мелатонина. Это способствует повышению аппетита, снижению затрат энергии. Кроме того, мелатонин играет главную роль в модуляции секреции адипокинов, влияя на метаболизм липидов. Снижение выработки мелатонина вызывает резистентность к инсулину и метаболическую циркадную дезорганизацию, приводящую к ожирению. Оценка роли мелатонина в развитии ожирения и сопутствующих ему патологий является перспективным направлением научных исследований в области диагностики, профилактики и лечения эндокринной и сердечно-сосудистой патологий.

In recent years, increasing attention of researchers has been paid to the role of melatonin in the regulation of body weight. When analyzing literature data, the problem of the mechanism of action of melatonin on the body and its use in the correction of metabolic disorders is considered. Disruption of circadian rhythms caused by the use of artificial light at night leads to decreased melatonin secretion. This helps increase appetite and reduce energy costs. In addition, melatonin plays a major role in modulating the secretion of adipokines by influencing lipid metabolism. Decreased melatonin production causes insulin resistance and metabolic circadian disorganization, leading to obesity. Assessing the role of melatonin in the development of obesity and its accompanying pathologies is a promising area of scientific research in the field of diagnosis, prevention and treatment of endocrine and cardiovascular pathologies.

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The authors declare that there are no conflicts of interest present.